MultiSource/Benchmarks/mafft/Lalign11.c

#include "mltaln.h"
#include "dp.h"

#define DEBUG 0
#define DEBUG2 0
#define XXXXXXX    0
#define USE_PENALTY_EX  1

static int localstop; // 060910

#if 1
static void match_calc( float *match, char **s1, char **s2, int i1, int lgth2 ) 
{
	char *seq2 = s2[0];
	int *intptr;

	intptr = amino_dis[(int)s1[0][i1]];
	while( lgth2-- )
		*match++ = intptr[(int)*seq2++];
}
#else
static void match_calc( float *match, char **s1, char **s2, int i1, int lgth2 )
{
	int j;

	for( j=0; j<lgth2; j++ )
		match[j] = amino_dis[(*s1)[i1]][(*s2)[j]];
}
#endif

#if 0
static void match_calc_bk( float *match, float **cpmx1, float **cpmx2, int i1, int lgth2, float **floatwork, int **intwork, int initialize )
{
	int j, k, l;
	float scarr[26];
	float **cpmxpd = floatwork;
	int **cpmxpdn = intwork;
	int count = 0;

	if( initialize )
	{
		for( j=0; j<lgth2; j++ )
		{
			count = 0;
			for( l=0; l<26; l++ )
			{
				if( cpmx2[l][j] )
				{
					cpmxpd[count][j] = cpmx2[l][j];
					cpmxpdn[count][j] = l;
					count++;
				}
			}
			cpmxpdn[count][j] = -1;
		}
	}

	for( l=0; l<26; l++ )
	{
		scarr[l] = 0.0;
		for( k=0; k<26; k++ )
			scarr[l] += n_dis[k][l] * cpmx1[k][i1];
	}
#if 0 /* ¤³¤ì¤ò»È¤¦¤È¤­¤Ïfloatwork¤Î¥¢¥í¥±¡¼¥È¤òµÕ¤Ë¤¹¤ë */
	{
		float *fpt, **fptpt, *fpt2;
		int *ipt, **iptpt;
		fpt2 = match;
		iptpt = cpmxpdn;
		fptpt = cpmxpd;
		while( lgth2-- )
		{
			*fpt2 = 0.0;
			ipt=*iptpt,fpt=*fptpt;
			while( *ipt > -1 )
				*fpt2 += scarr[*ipt++] * *fpt++;
			fpt2++,iptpt++,fptpt++;
		} 
	}
#else
	for( j=0; j<lgth2; j++ )
	{
		match[j] = 0.0;
		for( k=0; cpmxpdn[k][j]>-1; k++ )
			match[j] += scarr[cpmxpdn[k][j]] * cpmxpd[k][j];
	} 
#endif
}
#endif

static float Ltracking( float *lasthorizontalw, float *lastverticalw, 
						char **seq1, char **seq2, 
                        char **mseq1, char **mseq2, 
                        int **ijp, int *off1pt, int *off2pt, int endi, int endj )
{
	int i, j, l, iin, jin, lgth1, lgth2, k, limk;
	int ifi=0, jfi=0; // by D.Mathog, a guess
	char gap[] = "-";
	lgth1 = strlen( seq1[0] );
	lgth2 = strlen( seq2[0] );

#if 0
	for( i=0; i<lgth1; i++ ) 
	{
		fprintf( stderr, "lastverticalw[%d] = %f\n", i, lastverticalw[i] );
	}
#endif
 
    for( i=0; i<lgth1+1; i++ ) 
    {
        ijp[i][0] = localstop;
    }
    for( j=0; j<lgth2+1; j++ ) 
    {
        ijp[0][j] = localstop;
    }

	mseq1[0] += lgth1+lgth2;
	*mseq1[0] = 0;
	mseq2[0] += lgth1+lgth2;
	*mseq2[0] = 0;
	iin = endi; jin = endj;
	limk = lgth1+lgth2;
	for( k=0; k<=limk; k++ ) 
	{
		if( ijp[iin][jin] < 0 ) 
		{
			ifi = iin-1; jfi = jin+ijp[iin][jin];
		}
		else if( ijp[iin][jin] > 0 )
		{
			ifi = iin-ijp[iin][jin]; jfi = jin-1;
		}
		else
		{
			ifi = iin-1; jfi = jin-1;
		}
		l = iin - ifi;
		while( --l ) 
		{
			*--mseq1[0] = seq1[0][ifi+l];
			*--mseq2[0] = *gap;
			k++;
		}
		l= jin - jfi;
		while( --l )
		{
			*--mseq1[0] = *gap;
			*--mseq2[0] = seq2[0][jfi+l];
			k++;
		}

		if( iin <= 0 || jin <= 0 ) break;
		*--mseq1[0] = seq1[0][ifi];
		*--mseq2[0] = seq2[0][jfi];
		if( ijp[ifi][jfi] == localstop ) break;
		k++;
		iin = ifi; jin = jfi;
	}
	if( ifi == -1 ) *off1pt = 0; else *off1pt = ifi;
	if( jfi == -1 ) *off2pt = 0; else *off2pt = jfi;

//	fprintf( stderr, "ifn = %d, jfn = %d\n", ifi, jfi );


	return( 0.0 );
}


float L__align11( char **seq1, char **seq2, int alloclen, int *off1pt, int *off2pt )
/* score no keisan no sai motokaraaru gap no atukai ni mondai ga aru */
{
//	int k;
	register int i, j;
	int lasti, lastj;                      /* outgap == 0 -> lgth1, outgap == 1 -> lgth1+1 */
	int lgth1, lgth2;
	int resultlen;
	float wm = 0.0;   /* int ?????? */
	float g;
	float *currentw, *previousw;
#if 1
	float *wtmp;
	int *ijppt;
	float *mjpt, *prept, *curpt;
	int *mpjpt;
#endif
	static float mi, *m;
	static int **ijp;
	static int mpi, *mp;
	static float *w1, *w2;
	static float *match;
	static float *initverticalw;    /* kufuu sureba iranai */
	static float *lastverticalw;    /* kufuu sureba iranai */
	static char **mseq1;
	static char **mseq2;
	static char **mseq;
//	static int **intwork;
//	static float **floatwork;
	static int orlgth1 = 0, orlgth2 = 0;
	float maxwm;
	int endali = 0, endalj = 0; // by D.Mathog, a guess
//	int endali, endalj;
	float localthr = -offset;
	float localthr2 = -offset;
//	float localthr = 100;
//	float localthr2 = 100;
	float fpenalty = (float)penalty;
	float fpenalty_ex = (float)penalty_ex;


	if( orlgth1 == 0 )
	{
		mseq1 = AllocateCharMtx( njob, 0 );
		mseq2 = AllocateCharMtx( njob, 0 );
	}


	lgth1 = strlen( seq1[0] );
	lgth2 = strlen( seq2[0] );

	if( lgth1 > orlgth1 || lgth2 > orlgth2 )
	{
		int ll1, ll2;

		if( orlgth1 > 0 && orlgth2 > 0 )
		{
			FreeFloatVec( w1 );
			FreeFloatVec( w2 );
			FreeFloatVec( match );
			FreeFloatVec( initverticalw );
			FreeFloatVec( lastverticalw );

			FreeFloatVec( m );
			FreeIntVec( mp );

			FreeCharMtx( mseq );



//			FreeFloatMtx( floatwork );
//			FreeIntMtx( intwork );
		}

		ll1 = MAX( (int)(1.3*lgth1), orlgth1 ) + 100;
		ll2 = MAX( (int)(1.3*lgth2), orlgth2 ) + 100;

#if DEBUG
		fprintf( stderr, "\ntrying to allocate (%d+%d)xn matrices ... ", ll1, ll2 );
#endif

		w1 = AllocateFloatVec( ll2+2 );
		w2 = AllocateFloatVec( ll2+2 );
		match = AllocateFloatVec( ll2+2 );

		initverticalw = AllocateFloatVec( ll1+2 );
		lastverticalw = AllocateFloatVec( ll1+2 );

		m = AllocateFloatVec( ll2+2 );
		mp = AllocateIntVec( ll2+2 );

		mseq = AllocateCharMtx( njob, ll1+ll2 );


//		floatwork = AllocateFloatMtx( 26, MAX( ll1, ll2 )+2 ); 
//		intwork = AllocateIntMtx( 26, MAX( ll1, ll2 )+2 ); 

#if DEBUG
		fprintf( stderr, "succeeded\n" );
#endif

		orlgth1 = ll1 - 100;
		orlgth2 = ll2 - 100;
	}


	mseq1[0] = mseq[0];
	mseq2[0] = mseq[1];


	if( orlgth1 > commonAlloc1 || orlgth2 > commonAlloc2 )
	{
		int ll1, ll2;

		if( commonAlloc1 && commonAlloc2 )
		{
			FreeIntMtx( commonIP );
		}

		ll1 = MAX( orlgth1, commonAlloc1 );
		ll2 = MAX( orlgth2, commonAlloc2 );

#if DEBUG
		fprintf( stderr, "\n\ntrying to allocate %dx%d matrices ... ", ll1+1, ll2+1 );
#endif

		commonIP = AllocateIntMtx( ll1+10, ll2+10 );

#if DEBUG
		fprintf( stderr, "succeeded\n\n" );
#endif

		commonAlloc1 = ll1;
		commonAlloc2 = ll2;
	}
	ijp = commonIP;


#if 0
	for( i=0; i<lgth1; i++ ) 
		fprintf( stderr, "ogcp1[%d]=%f\n", i, ogcp1[i] );
#endif

	currentw = w1;
	previousw = w2;

	match_calc( initverticalw, seq2, seq1, 0, lgth1 );

	match_calc( currentw, seq1, seq2, 0, lgth2 );


	lasti = lgth2+1;
	for( j=1; j<lasti; ++j ) 
	{
		m[j] = currentw[j-1]; mp[j] = 0;
#if 0
		if( m[j] < localthr ) m[j] = localthr2;
#endif
	}

	lastverticalw[0] = currentw[lgth2-1];

	lasti = lgth1+1;

#if 0
fprintf( stderr, "currentw = \n" );
for( i=0; i<lgth1+1; i++ )
{
	fprintf( stderr, "%5.2f ", currentw[i] );
}
fprintf( stderr, "\n" );
fprintf( stderr, "initverticalw = \n" );
for( i=0; i<lgth2+1; i++ )
{
	fprintf( stderr, "%5.2f ", initverticalw[i] );
}
fprintf( stderr, "\n" );
#endif
#if DEBUG2
	fprintf( stderr, "\n" );
	fprintf( stderr, "       " );
	for( j=0; j<lgth2; j++ )
		fprintf( stderr, "%c     ", seq2[0][j] );
	fprintf( stderr, "\n" );
#endif

	localstop = lgth1+lgth2+1;
	maxwm = -999999999.9;
#if DEBUG2
	fprintf( stderr, "\n" );
	fprintf( stderr, "%c   ", seq1[0][0] );

	for( j=0; j<lgth2+1; j++ )
		fprintf( stderr, "%5.0f ", currentw[j] );
	fprintf( stderr, "\n" );
#endif

	for( i=1; i<lasti; i++ )
	{
		wtmp = previousw; 
		previousw = currentw;
		currentw = wtmp;

		previousw[0] = initverticalw[i-1];

		match_calc( currentw, seq1, seq2, i, lgth2 );
#if DEBUG2
		fprintf( stderr, "%c   ", seq1[0][i] );
		fprintf( stderr, "%5.0f ", currentw[0] );
#endif

#if XXXXXXX
fprintf( stderr, "\n" );
fprintf( stderr, "i=%d\n", i );
fprintf( stderr, "currentw = \n" );
for( j=0; j<lgth2; j++ )
{
	fprintf( stderr, "%5.2f ", currentw[j] );
}
fprintf( stderr, "\n" );
#endif
#if XXXXXXX
fprintf( stderr, "\n" );
fprintf( stderr, "i=%d\n", i );
fprintf( stderr, "currentw = \n" );
for( j=0; j<lgth2; j++ )
{
	fprintf( stderr, "%5.2f ", currentw[j] );
}
fprintf( stderr, "\n" );
#endif
		currentw[0] = initverticalw[i];

		mi = previousw[0]; mpi = 0;

#if 0
		if( mi < localthr ) mi = localthr2;
#endif

		ijppt = ijp[i] + 1;
		mjpt = m + 1;
		prept = previousw;
		curpt = currentw + 1;
		mpjpt = mp + 1;
		lastj = lgth2+1;
		for( j=1; j<lastj; j++ )
		{
			wm = *prept;
			*ijppt = 0;

#if 0
			fprintf( stderr, "%5.0f->", wm );
#endif
#if 0
			fprintf( stderr, "%5.0f?", g );
#endif
			if( (g=mi+fpenalty) > wm )
			{
				wm = g;
				*ijppt = -( j - mpi );
			}
			if( *prept > mi )
			{
				mi = *prept;
				mpi = j-1;
			}

#if USE_PENALTY_EX
			mi += fpenalty_ex;
#endif

#if 0 
			fprintf( stderr, "%5.0f?", g );
#endif
			if( (g=*mjpt+fpenalty) > wm )
			{
				wm = g;
				*ijppt = +( i - *mpjpt );
			}
			if( *prept > *mjpt )
			{
				*mjpt = *prept;
				*mpjpt = i-1;
			}
#if USE_PENALTY_EX
			*mjpt += fpenalty_ex;
#endif

			if( maxwm < wm )
			{
				maxwm = wm;
				endali = i;
				endalj = j;
			}
#if 1
			if( wm < localthr )
			{
//				fprintf( stderr, "stop i=%d, j=%d, curpt=%f\n", i, j, *curpt );
				*ijppt = localstop;
				wm = localthr2;
			}
#endif
#if 0
			fprintf( stderr, "%5.0f ", *curpt );
#endif
#if DEBUG2
			fprintf( stderr, "%5.0f ", wm );
//			fprintf( stderr, "%c-%c *ijppt = %d, localstop = %d\n", seq1[0][i], seq2[0][j], *ijppt, localstop );
#endif

			*curpt++ += wm;
			ijppt++;
			mjpt++;
			prept++;
			mpjpt++;
		}
#if DEBUG2
		fprintf( stderr, "\n" );
#endif

		lastverticalw[i] = currentw[lgth2-1];
	}


#if 0
	fprintf( stderr, "maxwm = %f\n", maxwm );
	fprintf( stderr, "endali = %d\n", endali );
	fprintf( stderr, "endalj = %d\n", endalj );
#endif

	if( ijp[endali][endalj] == localstop )
	{
		strcpy( seq1[0], "" );
		strcpy( seq2[0], "" );
		*off1pt = *off2pt = 0;
		return( 0.0 );
	}
		
	Ltracking( currentw, lastverticalw, seq1, seq2, mseq1, mseq2, ijp, off1pt, off2pt, endali, endalj );


	resultlen = strlen( mseq1[0] );
	if( alloclen < resultlen || resultlen > N )
	{
		fprintf( stderr, "alloclen=%d, resultlen=%d, N=%d\n", alloclen, resultlen, N );
		ErrorExit( "LENGTH OVER!\n" );
	}


	strcpy( seq1[0], mseq1[0] );
	strcpy( seq2[0], mseq2[0] );

#if 0
	fprintf( stderr, "wm=%f\n", wm );
	fprintf( stderr, ">\n%s\n", mseq1[0] );
	fprintf( stderr, ">\n%s\n", mseq2[0] );

	fprintf( stderr, "maxwm = %f\n", maxwm );
	fprintf( stderr, "   wm = %f\n",    wm );
#endif

	return( maxwm );
}