diff --git a/libomptarget/cmake/Modules/LibomptargetGetDependencies.cmake b/libomptarget/cmake/Modules/LibomptargetGetDependencies.cmake
index 8c93bd5..bbf2b98 100644
--- a/libomptarget/cmake/Modules/LibomptargetGetDependencies.cmake
+++ b/libomptarget/cmake/Modules/LibomptargetGetDependencies.cmake
@@ -50,52 +50,8 @@
 ################################################################################
 # Looking for libffi...
 ################################################################################
-find_package(PkgConfig)
-
-pkg_check_modules(LIBOMPTARGET_SEARCH_LIBFFI QUIET libffi)
-
-find_path (
-  LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIR
-  NAMES
-    ffi.h
-  HINTS
-    ${LIBOMPTARGET_SEARCH_LIBFFI_INCLUDEDIR}
-    ${LIBOMPTARGET_SEARCH_LIBFFI_INCLUDE_DIRS}
-  PATHS
-    /usr/include
-    /usr/local/include
-    /opt/local/include
-    /sw/include
-    ENV CPATH)
-
-# Don't bother look for the library if the header files were not found.
-if (LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIR)
-  find_library (
-      LIBOMPTARGET_DEP_LIBFFI_LIBRARIES
-    NAMES
-      ffi
-    HINTS
-      ${LIBOMPTARGET_SEARCH_LIBFFI_LIBDIR}
-      ${LIBOMPTARGET_SEARCH_LIBFFI_LIBRARY_DIRS}
-    PATHS
-      /usr/lib
-      /usr/local/lib
-      /opt/local/lib
-      /sw/lib
-      ENV LIBRARY_PATH
-      ENV LD_LIBRARY_PATH)
-endif()
-
-set(LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIRS ${LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIR})
-find_package_handle_standard_args(
-  LIBOMPTARGET_DEP_LIBFFI
-  DEFAULT_MSG
-  LIBOMPTARGET_DEP_LIBFFI_LIBRARIES
-  LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIRS)
-
-mark_as_advanced(
-  LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIRS
-  LIBOMPTARGET_DEP_LIBFFI_LIBRARIES)
+find_package(FFI QUIET)
+set(LIBOMPTARGET_DEP_LIBFFI_FOUND ${FFI_FOUND})
 
 ################################################################################
 # Looking for CUDA...
diff --git a/libomptarget/plugins-nextgen/CMakeLists.txt b/libomptarget/plugins-nextgen/CMakeLists.txt
index af2e5ef..882be30 100644
--- a/libomptarget/plugins-nextgen/CMakeLists.txt
+++ b/libomptarget/plugins-nextgen/CMakeLists.txt
@@ -19,71 +19,74 @@
 # - tmachine_libname: machine name to be appended to the plugin library name.
 macro(build_generic_elf64 tmachine tmachine_name tmachine_libname tmachine_triple elf_machine_id)
 if(CMAKE_SYSTEM_PROCESSOR MATCHES "${tmachine}$")
+  # Define macro to be used as prefix of the runtime messages for this target.
+  add_definitions("-DTARGET_NAME=${tmachine_name}")
+
+  # Define debug prefix. TODO: This should be automatized in the Debug.h but
+  # it requires changing the original plugins.
+  add_definitions(-DDEBUG_PREFIX="TARGET ${tmachine_name} RTL")
+
+  # Define the macro with the ELF e_machine for this target.
+  add_definitions("-DTARGET_ELF_ID=${elf_machine_id}")
+
+  # Define target triple
+  add_definitions("-DLIBOMPTARGET_NEXTGEN_GENERIC_PLUGIN_TRIPLE=${tmachine}")
+
+  add_llvm_library("omptarget.rtl.${tmachine_libname}"
+    SHARED
+
+    ${CMAKE_CURRENT_SOURCE_DIR}/../generic-elf-64bit/src/rtl.cpp
+
+    ADDITIONAL_HEADER_DIRS
+      ${LIBOMPTARGET_INCLUDE_DIR}
+
+    LINK_LIBS
+      PRIVATE
+      PluginCommon
+      ${OPENMP_PTHREAD_LIB}
+
+    NO_INSTALL_RPATH
+  )
+
   if(LIBOMPTARGET_DEP_LIBFFI_FOUND)
+     libomptarget_say("Building ${tmachine_libname} plugin linked with libffi")
+     target_link_libraries("omptarget.rtl.${tmachine_libname}" PRIVATE
+                           ${FFI_LIBRARIES})
+     target_include_directories("omptarget.rtl.${tmachine_libname}" PRIVATE
+                                ${FFI_INCLUDE_DIRS})
+  else()
+     libomptarget_say("Building ${tmachine_libname} plugie for dlopened libffi")
+     target_sources("omptarget.rtl.${tmachine_libname}" PRIVATE
+        ${CMAKE_CURRENT_SOURCE_DIR}/../generic-elf-64bit/dynamic_ffi/ffi.cpp)
+     target_include_directories("omptarget.rtl.${tmachine_libname}" PRIVATE
+        ${CMAKE_CURRENT_SOURCE_DIR}/../generic-elf-64bit/dynamic_ffi)
+  endif()
 
-    libomptarget_say("Building ${tmachine_name} NextGen offloading plugin.")
+  if(OMPT_TARGET_DEFAULT AND LIBOMPTARGET_OMPT_SUPPORT)
+    target_link_libraries("omptarget.rtl.${tmachine_libname}" PRIVATE OMPT)
+  endif()
 
-    # Define macro to be used as prefix of the runtime messages for this target.
-    add_definitions("-DTARGET_NAME=${tmachine_name}")
+  if(LIBOMP_HAVE_VERSION_SCRIPT_FLAG)
+    target_link_libraries("omptarget.rtl.${tmachine_libname}" PRIVATE
+      "-Wl,--version-script=${CMAKE_CURRENT_SOURCE_DIR}/../exports")
+  endif()
 
-    # Define debug prefix. TODO: This should be automatized in the Debug.h but
-    # it requires changing the original plugins.
-    add_definitions(-DDEBUG_PREFIX="TARGET ${tmachine_name} RTL")
+  # Install plugin under the lib destination folder.
+  install(TARGETS "omptarget.rtl.${tmachine_libname}"
+          LIBRARY DESTINATION "${OPENMP_INSTALL_LIBDIR}")
+  set_target_properties("omptarget.rtl.${tmachine_libname}" PROPERTIES
+    INSTALL_RPATH "$ORIGIN" BUILD_RPATH "$ORIGIN:${CMAKE_CURRENT_BINARY_DIR}/.."
+    POSITION_INDEPENDENT_CODE ON
+    CXX_VISIBILITY_PRESET protected)
 
-    # Define macro with the ELF ID for this target.
-    add_definitions("-DTARGET_ELF_ID=${elf_machine_id}")
+  target_include_directories("omptarget.rtl.${tmachine_libname}" PRIVATE
+                             ${LIBOMPTARGET_INCLUDE_DIR})
 
-    # Define target regiple
-    add_definitions("-DLIBOMPTARGET_NEXTGEN_GENERIC_PLUGIN_TRIPLE=${tmachine}")
-
-    add_llvm_library("omptarget.rtl.${tmachine_libname}"
-      SHARED
-
-      ${CMAKE_CURRENT_SOURCE_DIR}/../generic-elf-64bit/src/rtl.cpp
-
-      ADDITIONAL_HEADER_DIRS
-      ${LIBOMPTARGET_INCLUDE_DIR}
-      ${LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIR}
-
-        LINK_LIBS
-        PRIVATE
-        PluginCommon
-        ${LIBOMPTARGET_DEP_LIBFFI_LIBRARIES}
-        ${OPENMP_PTHREAD_LIB}
-
-      NO_INSTALL_RPATH
-    )
-
-    if ((OMPT_TARGET_DEFAULT) AND (LIBOMPTARGET_OMPT_SUPPORT))
-      target_link_libraries("omptarget.rtl.${tmachine_libname}" PRIVATE OMPT)
-    endif()
-
-    if (LIBOMP_HAVE_VERSION_SCRIPT_FLAG)
-      target_link_libraries("omptarget.rtl.${tmachine_libname}" PRIVATE
-        "-Wl,--version-script=${CMAKE_CURRENT_SOURCE_DIR}/../exports")
-    endif()
-
-    # Install plugin under the lib destination folder.
-    install(TARGETS "omptarget.rtl.${tmachine_libname}"
-      LIBRARY DESTINATION "${OPENMP_INSTALL_LIBDIR}")
-    set_target_properties("omptarget.rtl.${tmachine_libname}" PROPERTIES
-      INSTALL_RPATH "$ORIGIN" BUILD_RPATH "$ORIGIN:${CMAKE_CURRENT_BINARY_DIR}/.."
-      POSITION_INDEPENDENT_CODE ON
-      CXX_VISIBILITY_PRESET protected)
-
-    target_include_directories( "omptarget.rtl.${tmachine_libname}" PRIVATE
-      ${LIBOMPTARGET_INCLUDE_DIR}
-      ${LIBOMPTARGET_DEP_LIBFFI_INCLUDE_DIR})
-
-    list(APPEND LIBOMPTARGET_TESTED_PLUGINS "omptarget.rtl.${tmachine_libname}")
-    set(LIBOMPTARGET_TESTED_PLUGINS
-        "${LIBOMPTARGET_TESTED_PLUGINS}" PARENT_SCOPE)
-    set(LIBOMPTARGET_SYSTEM_TARGETS 
-        "${LIBOMPTARGET_SYSTEM_TARGETS} ${tmachine_triple} ${tmachine_triple}-LTO" PARENT_SCOPE)
-
-  else(LIBOMPTARGET_DEP_LIBFFI_FOUND)
-    libomptarget_say("Not building ${tmachine_name} NextGen offloading plugin: libffi dependency not found.")
-  endif(LIBOMPTARGET_DEP_LIBFFI_FOUND)
+  list(APPEND LIBOMPTARGET_TESTED_PLUGINS "omptarget.rtl.${tmachine_libname}")
+  set(LIBOMPTARGET_TESTED_PLUGINS
+      "${LIBOMPTARGET_TESTED_PLUGINS}" PARENT_SCOPE)
+  set(LIBOMPTARGET_SYSTEM_TARGETS 
+      "${LIBOMPTARGET_SYSTEM_TARGETS} ${tmachine_triple} ${tmachine_triple}-LTO" PARENT_SCOPE)
 else()
   libomptarget_say("Not building ${tmachine_name} NextGen offloading plugin: machine not found in the system.")
 endif()
diff --git a/libomptarget/plugins-nextgen/generic-elf-64bit/dynamic_ffi/ffi.cpp b/libomptarget/plugins-nextgen/generic-elf-64bit/dynamic_ffi/ffi.cpp
new file mode 100644
index 0000000..c79daa7
--- /dev/null
+++ b/libomptarget/plugins-nextgen/generic-elf-64bit/dynamic_ffi/ffi.cpp
@@ -0,0 +1,65 @@
+//===--- generic-elf-64bit/dynamic_ffi/ffi.cpp -------------------- C++ -*-===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+//
+// Implement subset of the FFI api by calling into the FFI library via dlopen
+//
+//===----------------------------------------------------------------------===//
+
+#include "llvm/Support/DynamicLibrary.h"
+#include <memory>
+
+#include "DLWrap.h"
+#include "ffi.h"
+
+DLWRAP_INITIALIZE()
+
+DLWRAP(ffi_call, 4);
+DLWRAP(ffi_prep_cif, 5);
+
+DLWRAP_FINALIZE()
+
+ffi_type ffi_type_void;
+ffi_type ffi_type_pointer;
+
+// Name of the FFI shared library.
+constexpr const char *FFI_PATH = "libffi.so";
+
+#define DYNAMIC_FFI_SUCCESS 0
+#define DYNAMIC_FFI_FAIL 1
+
+// Initializes the dynamic FFI wrapper.
+uint32_t ffi_init() {
+  std::string ErrMsg;
+  auto DynlibHandle = std::make_unique<llvm::sys::DynamicLibrary>(
+      llvm::sys::DynamicLibrary::getPermanentLibrary(FFI_PATH, &ErrMsg));
+  if (!DynlibHandle->isValid())
+    return DYNAMIC_FFI_FAIL;
+
+  for (size_t I = 0; I < dlwrap::size(); I++) {
+    const char *Sym = dlwrap::symbol(I);
+
+    void *P = DynlibHandle->getAddressOfSymbol(Sym);
+    if (P == nullptr)
+      return DYNAMIC_FFI_FAIL;
+
+    *dlwrap::pointer(I) = P;
+  }
+
+#define DYNAMIC_INIT(SYMBOL)                                                   \
+  {                                                                            \
+    void *SymbolPtr = DynlibHandle->getAddressOfSymbol(#SYMBOL);               \
+    if (!SymbolPtr)                                                            \
+      return DYNAMIC_FFI_FAIL;                                                 \
+    SYMBOL = *reinterpret_cast<decltype(SYMBOL) *>(SymbolPtr);                 \
+  }
+  DYNAMIC_INIT(ffi_type_void);
+  DYNAMIC_INIT(ffi_type_pointer);
+#undef DYNAMIC_INIT
+
+  return DYNAMIC_FFI_SUCCESS;
+}
diff --git a/libomptarget/plugins-nextgen/generic-elf-64bit/dynamic_ffi/ffi.h b/libomptarget/plugins-nextgen/generic-elf-64bit/dynamic_ffi/ffi.h
new file mode 100644
index 0000000..0ae0258
--- /dev/null
+++ b/libomptarget/plugins-nextgen/generic-elf-64bit/dynamic_ffi/ffi.h
@@ -0,0 +1,78 @@
+//===--- generic-elf-64bit/dynamic_ffi/ffi.cpp -------------------- C++ -*-===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+//
+// Provides a mirror to the parts of the FFI interface that the plugins require.
+//
+// libffi
+//   - Copyright (c) 2011, 2014, 2019, 2021, 2022 Anthony Green
+//   - Copyright (c) 1996-2003, 2007, 2008 Red Hat, Inc.
+//
+//===----------------------------------------------------------------------===//
+
+#ifndef DYNAMIC_FFI_FFI_H
+#define DYNAMIC_FFI_FFI_H
+
+#include <stddef.h>
+#include <stdint.h>
+
+#define USES_DYNAMIC_FFI
+
+uint32_t ffi_init();
+
+typedef struct _ffi_type {
+  size_t size;
+  unsigned short alignment;
+  unsigned short type;
+  struct _ffi_type **elements;
+} ffi_type;
+
+typedef enum {
+  FFI_OK = 0,
+  FFI_BAD_TYPEDEF,
+  FFI_BAD_ABI,
+  FFI_BAD_ARGTYPE
+} ffi_status;
+
+// These are target depenent so we set them manually for each ABI by referencing
+// the FFI source.
+typedef enum ffi_abi {
+#if (defined(_M_X64) || defined(__x86_64__))
+  FFI_DEFAULT_ABI = 2, // FFI_UNIX64.
+#elif defined(__aarch64__) || defined(__arm64__) || defined(_M_ARM64)
+  FFI_DEFAULT_ABI = 1, // FFI_SYSV.
+#elif defined(__powerpc64__)
+  FFI_DEFAULT_ABI = 8, // FFI_LINUX.
+#elif defined(__s390x__)
+  FFI_DEFAULT_ABI = 1, // FFI_SYSV.
+#else
+#error "Unknown ABI"
+#endif
+} ffi_cif;
+
+#ifdef __cplusplus
+extern "C" {
+#endif
+
+#define FFI_EXTERN extern
+#define FFI_API
+
+FFI_EXTERN ffi_type ffi_type_void;
+FFI_EXTERN ffi_type ffi_type_pointer;
+
+FFI_API
+void ffi_call(ffi_cif *cif, void (*fn)(void), void *rvalue, void **avalue);
+
+FFI_API
+ffi_status ffi_prep_cif(ffi_cif *cif, ffi_abi abi, unsigned int nargs,
+                        ffi_type *rtype, ffi_type **atypes);
+
+#ifdef __cplusplus
+}
+#endif
+
+#endif // DYNAMIC_FFI_FFI_H
diff --git a/libomptarget/plugins-nextgen/generic-elf-64bit/src/rtl.cpp b/libomptarget/plugins-nextgen/generic-elf-64bit/src/rtl.cpp
index 43569f2..7f66b68 100644
--- a/libomptarget/plugins-nextgen/generic-elf-64bit/src/rtl.cpp
+++ b/libomptarget/plugins-nextgen/generic-elf-64bit/src/rtl.cpp
@@ -383,6 +383,11 @@
     ompt::connectLibrary();
 #endif
 
+#ifdef USES_DYNAMIC_FFI
+    if (auto Err = Plugin::check(ffi_init(), "Failed to initialize libffi"))
+      return std::move(Err);
+#endif
+
     return NUM_DEVICES;
   }